This website monitors, summarizes, and provides links to current alcohol research articles in the journals listed at the left. The site is updated whenever a journal publishes a new issue, but we retain all our previous content to create a growing database that will become increasingly useful over time for researchers using our search engine. It's a powerful search engine that accepts Boolean operators and other useful searching tools.
Starting in October 2004, each new record in our database has a field containing standard search terms relevant to that record from the thesaurus developed for the National Institute on Alcohol Abuse and Alcoholism (NIAAA)*. (Click on "NIAAA Thesaurus" at the right.) Use of standard search terms makes searching more efficient. However, our search engine will also search on any terms you specify, including subjects, authors' names, article titles (all or in part), and journal name, month, year, etc.
Molecular biological, neurochemical, and behavioral approaches were used to test the hypothesis that the norepinephrine transporter (NET) contributes to the differences in ethanol-induced loss of righting reflex (LORR) in inbred Long-Sleep (ILS) and inbred Short-Sleep (ISS) mice. The aim was to investigate the NET as a candidate gene contributing to this phenotype. The ILS and ISS mice carry different deoxyribonucleic acid haplotypes for NET, showing eight silent differences between allelic coding regions. Only the ILS haplotype is found in other mouse strains thus far sequenced. Brain regional analyses revealed that ILS mice have 30% to 50% lower [3H]NE uptake, NET binding, and NET messenger ribonucleic acid levels than ISS mice. Maximal [3H]NE uptake and NET number were reduced, with no change in affinity, in the ILS mice.
The purpose was to determine whether there is a relationship between alcohol preference and high bone mass or strength and whether bone mass-regulating genes segregate during selective breeding of alcohol preferring rats. Six different lines of male rats with high or low preference for alcohol consumption were studied. The high alcohol preference lines were alcohol-preferring (P), high-alcohol-drinking 1 (HAD1), and high-alcohol-drinking 2 (HAD2). Their corresponding low alcohol preference lines were alcohol-nonpreferring (NP), low-alcohol-drinking 1 (LAD1), and low-alcohol-drinking 2 (LAD2). Bone mass phenotypes were determined using dual energy x-ray absorptiometry, peripheral quantitative computed tomography, and biomechanics in long bones and lumbar vertebrae from rats at 3 and 6 months of age. Bone mass and strength were significantly higher in P rats than in NP rats, mainly due to higher cortical bone in long bones and lumbar vertebrae.
The purpose was to determine whether there is a relationship between alcohol preference and high bone mass or strength and whether bone mass-regulating genes segregate during selective breeding of alcohol preferring rats. Six different lines of male rats with high or low preference for alcohol consumption were studied. The high alcohol preference lines were alcohol-preferring (P), high-alcohol-drinking 1 (HAD1), and high-alcohol-drinking 2 (HAD2). Their corresponding low alcohol preference lines were alcohol-nonpreferring (NP), low-alcohol-drinking 1 (LAD1), and low-alcohol-drinking 2 (LAD2). Bone mass phenotypes were determined using dual energy x-ray absorptiometry, peripheral quantitative computed tomography, and biomechanics in long bones and lumbar vertebrae from rats at 3 and 6 months of age. Bone mass and strength were significantly higher in P rats than in NP rats, mainly due to higher cortical bone in long bones and lumbar vertebrae.